Although the technology is changing rapidly, large-scale e-mail communication is unreliable at this point in time, and should be used with caution. E-Mail addresses change rapidly. Those of you who maintain a large database of addresses and phone numbers know how difficult it is to keep contact information up-to-date. E-Mail addresses are far more volatile than physical addresses.
Delivery to accurate Email addresses is further impacted by both personal and organizational attempts to deal with the massive amounts of unsolicited E-Mail being sent every day, as well as concerns about the use of email to spread worms and viruses. Still, this valuable resource, properly used, can help strengthen you organization.
Make sure that any vendor who offers you E-Mail services does "SMTP-Level Validation" of every E-Mail address they use on your behalf.